MCQs on Introduction to Pharmacology, Pharmacodynamics and Pharmacokinetic: Pharmacology

Introduction to Pharmacology, Pharmacodynamics, and Pharmacokinetic 

Multiple Choice Question 

1) A molecule that interacts as an activator or inhibitor and brings about a change in the biological function through its chemical actions is known as ………………..
a) Drug

b) Hormone
c) Neurotransmitter
d) Protein

2) The action of the drug on the body is known as ……………………….
a) Pharmacokinetic
b) Pharmacodynamic
c) Pharmacology
d) Pharmacotherapeutics

3) Which one of the following statements is correct?
a) Weak bases are absorbed efficiently across the epithelial cells of the stomach
b) Co-administration of atropine speed up the absorption of a second drug
c) Drugs showing a large Vd can be efficiently removed by dialysis of the plasma
d) Weak acids are absorbed efficiently across the epithelial cells of the stomach

4) The desired physicochemical properties of drugs are:
a) Ionized, less plasma protein bound, lipid soluble
b) Unionized, less plasma protein bound, lipid soluble
c) Unionized, highly plasma protein bound, lipid soluble
d) Unionized, highly plasma protein bound, lipid-insoluble

5) Which of the following statement about receptor is not true?
a)  It determines the quantitative relations between dose or concentration of drug and pharmacologic effects.
b) Responsible for the selectivity of drug action.
c) Mediates the actions of pharmacological agonists and antagonists.
d) None of the above

6) The efficacy of agonist is reduced without affecting its potency is found in ………………….
a) Antagonism.
b) Noncompetitive
c) Competitive
d) Non-competitive and competitive
d) Inverse

7) Which of the following statement about competitive antagonism is true?
a) Can cause a parallel shift to the right in a drug-response curve for agonist
b)  Can be reversed by increasing dose of agonist
c) Appear to decrease the potency of the agonist
d) All of the above
e) None of the above

8) Which of the following effect can be seen in competitive antagonism in a drug-response curve?
a) Non-parallel left shift
b) Non-parallel right shift
c) Parallel right shift
d) Parallel left shift

9) Agonists have
a) Affinity to receptors only
b) Affinity and maximal intrinsic activity
c) Affinity but no intrinsic activity
d) Affinity and submaximal intrinsic activity

10) The IV administration of drugs are
a) 100% bioavailable
b) Rapidly absorbed
c) Undergoes the first-pass metabolism
d) Rapidly excreted by renal

11) The concentration of a drug required to produce 50% of that drug’s maximal effects is termed as ……………….
a) Efficacy
b) Potency
c) Affinity
d) Bioavailability 

12) For a drug given orally, the principal site of drug absorption is ……………………
a) Stomach
b) Small intestine
c) Oesophagus
d) Large intestine

13) Biotransformation of the drugs may lead to all of the following except
a) Inactive metabolite from an active drug
b) Active metabolite from an active drug
c) Active metabolite from an inactive drug
d) Inactive metabolite from inactive drug

14) Depot of the drug can be formed by …………………….
a) Subcutaneous and intramuscular route
b) Intravenous route
c) Subcutaneous route
d) Intradermal and subcutaneous route

15) Conjugation of a drug with glucuronic acid via glucuronosyl transferase with result in all of the following except
a) production of a more water-soluble moiety that is more easily excreted
b) a drug with a different pharmacological mechanism of action
c) a new compound that may also possess pharmacologic activity
d) a drug molecule that may undergo enterohepatic recirculation and reintroduction into the bloodstream

18) All of the following concerning the blood-brain barrier (BBB) and the passage of drugs from the systemic circulation to cerebrospinal fluid (CSF) is true except
a) ionized drugs are likely to cross into the CSF than unionized drugs
b) the higher the lipid solubility of a drug, the more likely it will cross into the CSF
c) inflammation of the meninges improves the likelihood that drugs will cross the BBB as compared to an uninflamed state

17) P glycoprotein serves to pump back the drugs into the systemic circulation from endothelial cell linings of the BBB
The following log dose-response curve show that

a) Drug A and B have equal potency
b) Drug B and C have equal efficacy
c) Drug A and B have equal efficacy
d) Drug A and C have the same affinity and efficacy

18) Phase II metabolism associated with a genetic polymorphism is ………………………….
a) Acetylation
b) Glutathione conjugation

c) Oxidation

d) Reduction

19) When the same dose of a drug is repeated at half-life intervals, the steady-state plasma drug concentration is reached after:
a) 2-3 half-lives
b) 4-5 half-lives
c) 6-7 half-lives
d) 8-10 half-lives

20) An ‘orphan drug’ is
a) A very cheap drug
b) A drug which has no therapeutic use
c) A drug which acts on orphan receptors
d) A drug needed for treatment or prevention of a rare disease

Multiple Choice Answers
1-a) Drug
2-b) Pharmacodynamic
3-d) Weak acids are absorbed efficiently across the epithelial cells of the stomach
4-a) Ionized, less plasma protein bound, lipid soluble
5-d) None of the above
6-a) Noncompetitive
7-d) All of the above
8-c) Parallel right shift
9-b) Affinity and maximal intrinsic activity
10-a) 100% bioavailable
11- b) Potency
12- b) small intestine
13- d) Inactive metabolite from inactive drug
14-a) Subcutaneous and intramuscular route
15-b) a drug with a different pharmacological mechanism of action
16-a) ionized drugs are likely to cross into the CSF than unionized drugs
17-b) Drug B and C have equal efficacy
18-a) Acetylation
19-b) 4-5 half-lives
20-d) A drug needed for treatment or prevention of a rare disease