MCQ on Circulatory Pathology : Clinical Pathology

                    MCQ on Circulatory Pathology : Clinical Pathology

1) Edema is the presence of excess fluid in the intracellular space. 

The increased hydrostatic pressure causes edema in which of the following condition?
a) Congestive failure

b) Portal Hypertension

c) Venous Thrombosis

d) All of the above

e) None of the above

2) Which of the following condition causes edema with hypoalbuminemia & decreased colloid osmotic pressure?

a) Nephrotic syndrome

b) Primary hyperaldosteronism 

c) Renal Failure

d) Graves disease

3) Which of the following disease is associated edema caused by increase endothelial permeability?

a) Hypersensitivity reaction type I

b) Bleomycine treatment

c) Renal failure

d) Graves disease

4) Exudate is the type of edema with high protein content and cells. 

Which of the following are true for exudate?

a)  Results from increased vascular permeability caused by inflammation

b) Specific gravity of the content is less than 1.020

c) Contain a large number of inflammatory leukocytes

d) Higher glucose content in the fluid

5) Which of the following are the associated pathology of edema caused by heart failure?

a) Decreased capillary pressure

b) Increased renal blood flow

c) Increased sodium and water retention

d) Decreased blood volume

 

6) Primary hemostasis is a process of the formation of the platelet plug. 

Which of the following are the correct sequential steps of primary hemostasis?

a) Recruitment, platelet adhesion, shape change, granule release, aggregation of platelets

b) Granule release, platelet adhesion, shape change, granule release, recruitment, aggregation of platelets

c) Platelet adhesion, Shape change, granule release, recruitment, aggregation of platelets

d) Platelet adhesion, granule release, recruitment, shape change, aggregation of platelets

7) Which of the following bleeding disorder is associated with a protein that is involved in platelet adhesion and activation?

a) Glanzmann thrombasthenia- deficiency of GpIIb-IIIa

b) von Willebrand disease

c) Bernard-Soulier syndrome deficiency of GpIb

d) All of the above

e) None of the above

8) Immune thrombocytopenia purpura (ITP) is an immune-mediated attack (usually IgG antiplatelet antibodies) against platelets leading to decreased platelets (thrombocytopenia) which result in petechiae, purpura (bruises), and a bleeding diathesis (e.g., hematomas). 

Lab investigations show the following, Except

a) Decreased platelet count 

b) Prolonged bleeding time, prothrombin time, and partial thromboplastin time 

c) Thrombocytopenia with enlarged immature platelets (mega thrombocytes)

d) Increased numbers of megakaryocytes in bone marrow biopsy

9) Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of hemostasis in which there is the widespread intravascular formation of fibrin-platelet thrombi. 

TTP is caused by deficiency of the enzyme................................ 

a) Factor IX

b) ADAMTS13

c) GPIb

d) vW protein

Answers:

1-d) All of the above

2-
a) Nephrotic syndrome

3-a) Hypersensitivity reaction type I & b) Bleomycine

4- Option a) & c)

5- c) Increased sodium and water retention

6-Platelet adhesion, Shape change, granule release, recruitment, aggregation of platelets

7-d) All of the above

8-b) Prolonged bleeding time, prothrombin time, and partial thromboplastin time

9-b) ADAMTS13